Skip to main content.
Visit our healthcare provider site


Cortoss gun

Cortoss is an advanced, injectable, synthetic, non-resorbable biomaterial which mimics the mechanical properties of cortical (weightbearing) bone1. Cortoss was developed to provide an ideal bone augmentation solution for treatment of vertebral compression fractures (VCFs). It has been clinically proven to match the safety and effectiveness of Polymethylmethacrylate (PMMA) for vertebral augmentation.2


  • Flow and fill: properties improve short-term pain and long-term function2
  • Safety: low incidence of adjacent fractures2; minimal exotherm3 and monomer release4
  • Control: procedural flexibility with mix-on-demand and start/stop delivery5
  • Robust compilation of clinical data2 

Cortoss cartridge

Multi-center clinical trials provide the proof:
  • The safety and efficacy of Cortoss have been demonstrated in three U.S. clinical investigations and multiple European studies2
  • In patients with a first-time fracture at one level, there was a 43% reduction in adjacent level fractures in the Cortoss patient population26
  • Compared to PMMA, Cortoss is more hydrophilic, which enables it to coat and augment the internal structure of the vertebral body2. This interdigitating characteristic resulted in a 30% reduction in material injected when compared to PMMA in a controlled study2
  • The level 1 IDE Study showed a statistically significant increase in the percentage of patients experiencing a reduction in short-term pain at 3 months and improvement of long-term function at 24 months2